Background: Hepatocellular carcinoma is the world's fifth most common cancer and the second biggest cause of cancer-related death. HCC patients encounter a wide range of symptoms that are severe enough to affect their quality of life. Nurses must develop collaborative, multidisciplinary symptom treatment strategies.  Aim: Evaluate the effect of implementing early palliative care on hepatocellular carcinoma patients' outcomes. Subjects and method: design: Quasi-experimental design was utilized. Subjects: proposed Sample of 114 adult patients aged 20 - 60 years old of both sexes who diagnosed of hepatocellular carcinoma.The research was carried out in both inpatient and outpatient clinics for patients follow up at Mahalla Hepatology Educational Hospital affiliated to Ministry of Health. Tools: Four tools were used for the collection of the necessary data and achieving the aim of the study as follows; Interview questionnaire sheet, FACT-Hep Version4, ESAS, CES-Dep.   Results: Revealed that there was significant improving effect regarding total score of FACT-Hep, ESAS, and CES-Dep two weeks post implementation of early palliative care and in follow up. Conclusion: The study concluded that the early palliative care improves the quality of life, relieves pain and other symptoms either from the disease or from the treatment and improves mood in patients with hepatocellular carcinoma. Recommendations: Early palliative care should be initiated early once the patient diagnosed in order to be integrated with medical treatment. This research has provided a starting point for further studies regarding health services research in palliative care.