Background: Simulation is constantly being used by nurses and other health practitioners as a method for teaching and learning at all stages of clinical training. Aim: Assess the effect of high fidelity simulation on students' knowledge of obstetrics emergencies, confidence and satisfaction at faculty of nursing Port Said University. Subjects and method: Design: A quasi-experimental research design was used. Setting: Clinical obstetric laboratory skills, Faculty of nursing Port Said University, Port Said governorate, Egypt. subjects:  All students in third year (120 students) who completed their maternity nursing courses of the academic year 2019-2020. Tools: A structured interviewing questionnaire, NursOB scale and satisfaction likert scale were used. Results: Statistically significant improvement were revealed in all areas of tested knowledge regarding clinical simulation and different obstetrical and gynecological emergencies at the post (P=.005) and follow-up phases (P=.000). Also, statistically significant improvement in confidence level were revealed at the post (92.60%) and follow-up phases (52.80%). Mean score of student nurses satisfaction 4.60 ± 0.487 about high fidelity simulation training program compared to 3.88±0.63 at pre programme phase. In addition, statistically significant positive correlation between total satisfaction, knowledge and confidence level (P =.010). Conclusion: High-fidelity simulation is an important teaching method that allow nursing students to acquire the needed clinical knowledge, confidence level as well as satisfaction that allow them to apply management of obstetric emergencies. Recommendations: To ensure safety in management of various obstetric emergencies, more high-fidelity simulation should be used instead of traditional clinical practice in the nursing student's educational curriculum.