Background:Cirrhosis of the liver is the end stage of chronic liver disease. Nurses role very important to patient with liver cirrhosis. Aim:Assess nurses^, knowledge and practice regarding nursing care of patients with liver cirrhosis. Subjects and Method:A descriptive research design was used. Setting: The study was conducted  medical unit at Ismailia university hospital, Ismailia general hospital and Port-Said general hospitals (Port-Said, Port-Fouad and AL-Zehor central). Subjects: A 150 convenient nurses participated in the study Tools: Data were collected using two tools, Nurses' Knowledge questionnaire and Observational Check list for practice. Result: The result of study indicated that 78.65% and 63.09% of studied nurses had unsatisfactory knowledge and practice Conclusion: Most of the studied nurses had unsatisfactory knowledge and practice regarding care of patients with liver cirrhosis. Recommendations: There are obvious needs for conducted an educational and training programs to improve nurse's knowledge and practice regarding nursing care of patients liver cirrhosis.