Background:Tuberculosis (TB) has been ranked to be one of the top ten causes of global mortality worldwide. The concept of health-related quality of life (HRQOL) might be of a multi-dimensional nature, it includes psychological, physical and social aspects. The effectiveness of medical interventions is influenced by adherence. Aim: This study aims to assess the correlation between health related quality of life (HRQOL) and medication adherence for Patients with pulmonary tuberculosis. Subjects and Method: A design based on descriptive correlational research was utilized. Convenient sample of pulmonary tuberculosis patients (56) at Almasaha Albahary at Port Said City and Chest Hospital at Damietta City. Three structured interviews were utilized to gather the required data. Data collection tools: Tool I: structured interviewing questionnaire, Tool II: Health Related Quality of life for patients with chronic illness, Tool III: Morisky Medication Adherence Scale (MMAS-8). Results: this study showed that 67.9% of the subjects were high psychological domain of health related quality of life and moreover, 75% of them were highly adhered to medications. Conclusion:  it can conclude that three fifth of the studied patients had high QOL and three quarters of the patients had high adherence to medication. This study showed that there was statistically positive correlation between HRQOL domains (Physical, psychological, social) of HRQOL and drug adherence. Recommendation: the study recommended the event of program for patients with TB to enhance the patients' knowledge, care management and modify their wrong beliefs associated with TB.