Background: Hypovolemic shock is a severe life threatening emergency affecting all organ systems. Nurses play a vital role in caring of patients with post traumatic hypovolemic shocked. Aim: Assess nurses ^'knowledge and practice regarding patients with post traumatic hypovolemic shock. Subjects and Method: A descriptive research design was used. Setting: The study was conducted in intensive care unit in Damietta general hospital and port-said governmental hospitals Subjects: A convenient sample of 50 nurses participated in the study Tools: data was collected using two tools, Nurses' Knowledge questionnaire and observational check list for nurses' practice. Results: The result of study indicated that 54% of studied nurses had satisfactory knowledge while 66% had satisfactory practice Conclusion: More than half of the studied nurses had satisfactory knowledge and practice regarding patients with post traumatic hypovolemic shocked. Recommendations: There are obvious needs for conducting in-service educational and training programs to improve nurses' knowledge and practice regarding patients with post traumatic hypovolemic shock.