Background: Diabetic foot ulcer represents a major global medical, social and economic problem. It is the commonest major end-point of diabetic complications. Patients with a Diabetic foot ulcer need to be assessed holistically to identify intrinsic and extrinsic factors. Aim: This study aimed to determine the relationship between diabetic patients' knowledge regarding diabetic foot ulcer care and their wound status at Port Said general hospitals. Subjects and Methods: A descriptive correlational design was applied in the current study. The study was conducted in surgical outpatient clinics at hospitals affiliated to the ministry of health in port said city. A convenient sample included 109 patients with diabetic foot ulcer. Two tools were used for data collection; Foot care knowledge questionnaire and Bates-Jensen Wound Assessment. Results of the study showed more half of the studied  had satisfactory Knowledge regarding diabetic foot ulcer care. Although the majority of patients had wound regeneration. Conclusion: there no statistically significance relation between patient's knowledge regarding diabetic foot care and their wound status. The current study recommended that, further studied should be carried out to investigate risk factors for the development of diabetic foot ulcer and wound healing rate.