Background: Epilepsy is a major health problem frequently seen among school children. Children having seizures may bother their parents and teachers, who do not receive specific training during their education. Moreover, teachers feel desperate not knowing how to handle the situation. Not only the disease itself, but also the drugs used may lead to certain cognitive, psychosocial and behavioral problems. The aim: of this study was to evaluate the effect of health educational program on knowledge regarding epilepsy and its management among primary schools' teachers, in Port Said city. It was hypothesized that the primary schools' teachers' knowledge will significantly improve after implementation of the educational program. The study was conducted in primary schools in Port Said city on sample of 143 teachers. Using a quasi-experimental research design. A health teaching program about epilepsy and its treatment was developed by researchers, teachers' general knowledge about epilepsy and its treatment was tested before and after giving the health program using a self-administered questionnaire. The Results: The findings indicated an improvement of the teachers' knowledge about various items of epilepsy and also in its management. There was a strong significant correlation between teachers' knowledge about epilepsy and their level of education and their income.  In conclusion, the health education program to teachers improves their knowledge about epilepsy and its management. In the light of this finding, it will have recommended that, educational programs must be carried out periodically in primary schools for all teachers to provide them with proper knowledge and skills necessary for helping epileptic children.