The aim of the present study was to investigate the effectiveness of multicultural approach in developing oral communication skills in English of Al-Azhar Experimental Secondary Institute Students. The participants of the study were (64) female students who were selected at random from Al-Zohor Experimental Secondary Institute for Girls at Port-Said. They were divided into two groups ; control and experimental. To identify the most required oral communication skills to be developed, a questionnaire containing list of oral communication skills were designed for validation by TEFL specialists. Based on the selected skills, the researcher designed a pre-post test oral communication skills test validated by the jury members. Both groups were pre-tested. Then, the experimental group students were taught using multicultural approach whereas the control group students received regular instruction. Again, both groups were post tested. The results of administering  the oral communication pre-post test showed that that a multicultural approach proved to be effective in developing oral communication skills in English of Al-Azhar Experimental Secondary Institute Students.