Effect of preinoculation of mycorrhizal fungus (Glomus fasiculatum) on growth and tolerance of cowpea plants irrigated with different concentrations of waste effluents from industrial fertilizers was studied. The results indicated that, the relative growth rate, dry weight, nodule formation, total pigment content as well as tolerance indices of mycorrhizal cowpea plants were significantly reduced by irrigation with different levels of polluted water. Mycorrhizal association was found not only to improve all above parameters but also aid in overcoming the detrimental growth effect of irrigated water pollution. The results also revealed that, macro- -and micro-element contents, (P, N, Na, Mg, Cu, Co, Zn and Fe) of cowpea plants grown on polluted soil were much higher than that of unpolluted one. Results emphasized that VA mycorrhizal symbiosis can increase metal tolerance of cowpea plants. The VA mycorrhizal symbiosis could accumulate the heavy metals Co, Zn, Fe in mycorrhizal plant root than that of mycorhizal plant shoot. The percentage of VA mycorrhizal infection showed marked reduction with raising the pollution level. Evidently from the results proved that mycorrhizal dependencies for plant dry mass decreased at 10 & 20% pollution level, but, it increased at higher pollution level (40%).