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186326

SYNTHESIS OF SOME PYRIMIDO-[4', 5' : 4,5]-PYRIMIDO-[ 1,6-a ]INDOLE OF POTENTIAL ANTIINFLAMMATORY AND ANTIPYRETIC ACTIVITIES

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Last updated: 22 Jan 2023

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Abstract

The synthesis of 12,12a-dihydropyrimido-[4',5' : 4,5]-pyrimido-[1,6-a]-indole-1,6[ 2H, 5H]-dione is described. Treatment of enaminonitriles I with chloroacetyl chloride afforded the tetracyclic compounds II. In contrast compound I with nuorophenyl group at position 2 gave N-chloroacetylamino derivatives III which underwent cyclization either by acid or base. Preliminary Pharmacological screening of some compounds showed significant antiinflammatory and antipyretic activities.

DOI

10.21608/zjps.1995.186326

Authors

First Name

Mohamed

Last Name

Ebeid

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt

Email

mohamed.ebeid@yahoo.com

City

-

Orcid

-

First Name

Sayed

Last Name

Lashine

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt

Email

smlashine@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Sobhy

Last Name

El-Adl

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt

Email

smel-adl@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Mansour

Last Name

Abou-Kull

MiddleName

-

Affiliation

Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt

Email

meabou-kull@pharmacy.zu.edu.eg

City

-

Orcid

-

Volume

4

Article Issue

1

Related Issue

24771

Issue Date

1995-06-01

Receive Date

1995-02-03

Publish Date

1995-06-01

Page Start

36

Page End

42

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 4_Issue 1_Pages 36-42.pdf

PDF . 3.3MB

Link

https://zjps.journals.ekb.eg/article_186326.html

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https://zjps.journals.ekb.eg/service?article_code=186326

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7

Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

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Article

Created At

22 Jan 2023