The aim of the present study was directed to evaluate the therapeutic efficacy of chrysin (CH) on acrylamide (ACR) induced striated muscles dystrophy of rat's tongue. subjects and methods: Forty adult male albino rats (200–250 g) were divided into four equal group(s) (G(s)), used for two successive periods (20 days: A , 40 days: B). G1 were fed with standard diet, without receiving any kind of treatment and considered as negative control group. G2 were received 15 mg/kg body weight of ACR orally once daily for 20 days (G2A) and for 40 days (G2B) and considered as positive control group. G3 were treated as G2, in addition; they were received 50 mg/kg intraperitoneal of CH two weeks before, as well as during application of ACR on alternative days and considered as a chemopreventive group. G4 were treated as G2, in addition; they were received 50 mg/kg intraperitoneal of CH, at first, third and seventh days after application of ACR and considered as a treatment group. Results: G1 has no observable abnormalities. G2A and G2B revealed an increase in collagen fibers with degenerative changes. G3A and G3B revealed decreased collagen fibers with muscle regeneration. G4A revealed localized red swelling of tongue mucosa, diffuse in G4B. Both had limited areas of collagen fibers. Conclusion: Striated muscle damage in rat's tongue by ACR becomes worse with prolonged duration is realized. CH has a significant protective efficacy of when compared with that of treatment on ACR induced striated muscle injury of rat's tongue.