Field experiment was carried out at, Qalubia Governorate, Egypt during winter season 2015 to evaluate the effect of inoculation with Bacillus ssp., compost and fulvic acid application on wheat. Results indicated that the highest increase of total count of bacteria, dehydrogenase and nitrogenase enzymes was obtained with T8 (biofertilization combined with fulvic acid and compost equal half dose of NPK) and T7(biofertilization combined with fulvic acid  with equal half dose of NPK) compared with control after 60 and 90 days of planting. Also, T8 recorded the highest increase in all pigments (Chl. a, Chl. b and carotenoids) comparison with control after 60 and 90 days. Also, T8 gave the highest values in total NPK content. On the other hand, T8 induced high significant decrease in Na⁺ content after 60 and 90 days of planting. On the other hand the low activities of catalase and peroxidase in shoot were observed in T8 compared with control. Also, proline content of shoots and roots significantly increased under salinity stress. T8 recorded the lowest value comparison with control.Also, the grain, straw yield and N, P, K in grain were highest value with T8 compared with control.