Background: Standard Precautions(SP) are the minimum infection prevention practices that apply to all patient care, regardless of suspected or confirmed infection status of the patient. Aim of the study : Was to assess factors that influence nurses' compliance with standard precautions regarding occupational exposures to blood and body fluids. Subjects and Method: Research Design: A descriptive exploratory study design was used. Setting: The study was conducted at Faqous General Hospital in Sharkia governorate, Egypt. Subject: A Convenience sample of 86 nurses. Tools of data collection: Two tools were used Tool I. A self-administered questionnaire composed of four part: part 1: Concerned with nurses' demographic data. part 2: Covered nurses' occupational exposures rate to blood and body fluids, part 3:Revealed nurses' compliance with standard precaution and part 4: Covered the factors influencing nurses' compliance with (SP) included ,the hospital factors, nurses' attitude and nurses' knowledge. Tool II: Observational checklist to assess nurses' practice. Results: The study finding revealed that the nurses median age was 30.0 years,76.7% were females,68.6% of the sample had previous occupational exposure , 87.2% of the nurses were compliant with standard precaution, 68.6% of the nurses had satisfactory knowledge on standard precautions ,75.6% had satisfactory practice ,Additionally there were a significant positive correlations between nurses compliance scores on standard precaution and hospital related factors(r = 0.267). Conclusion : Hospital staff nurses are at a significant risk of exposure to blood and body fluids. The majority of the nurses were compliant with standard precaution. While, more than two third of nurses had satisfactory total knowledge regarding (SPs) Recommendations: Maximizing the hospital role in updating the staff 'knowledge about standard precautions through empowering an infection control committee .