Chronic renal failure in adolescents is a major health problem and is considered as the most common chronic disease of childhood. So, the compliance to management plan is necessary to improve nutritional status, reduce uremia toxicity and delay renal deterioration and other problems associated with end stage renal failure and dialysis. Therefore, the aim of this study was to evaluate the compliance of the adolescents with chronic renal failure to their management plan. The study was carried out at out- patient clinic of the nephrology unit and hemodialysis unit at Mansoura Children's UniversityHospital. The sample consisted of 50 adolescents with chronic renal failure. Two tools were used for data collection. The first tool was a structured interview sheet, which designed by the researcher and included sociodemographic characteristics of adolescents and their dietary, fluid and medications compliance.  Second tool was Adherence Scale which was developed by the researcher  guided by Jacobson et al. (1990) to assess the level of compliance of adolescents to their management plan. The results revealed that adolescents' compliance about dietary program, fluid intake, and measurement of vital signs, medications, blood analysis, daily activities and follow – up were lacked in the first visit and improved significantly in the second and third visits. Therefore, establishment of continuous educational programs and hand out for adolescents with chronic renal failure to provide them with the essential knowledge about disease and its management plan are recommended