Each organism has its unique and specific characteristics that have a great impact on the survival and adaptation processes. One of the most amazing and remarkable characteristics in some organisms such as crustaceans, cephalopods and some insects is the reversible color change property in their skin. This color change happens for various reasons such as thermoregulation, camouflage, and mating. It occurs due to the existence of the chromatophore, which is a special sort of pigment cells in their skin compositions. Chameleons are one of the most spectacular organisms that have this unique capability. This paper aims to demonstrate the property of chameleon' reversible color change skin, its mechanism, and its applications in Architecture. In order to achieve this goal, different types of materials and glazing technologies that imitate this property and their applications in building's skin have been displayed. Besides, a schematic proposed framework inspired from the chameleon' skin has been introduced.