Behçet's disease (BD) is a chronic inflammatory disease with multisystem involvement. It presents with remission and exacerbation. The aim of our study was to study the pattern of Behcet's disease among patients attending the Rheumatology and Rehabilitation Department, SohagUniversity. Conclusion: Behcet's disease starts frequently around the beginning of the third decade and has a male predominance (70%). The age at diagnosis of Behcet's disease ranged from 19-59 years, with a mean of around 28.8 years. Most of the cases in our study were married (73.3%). It was found that the most common first manifestation in our study group was oral ulcers, followed by ocular manifestations, then CNS manifestations, articular or vascular manifestations and lastly genital ulcer or skin manifestations.