Hepatitis C virus (HCV) is considered the most common etiology of chronic liver disease in Egypt. Developing non invasive tests that can predict liver injury represents a growing medical need.  Considering that hepatocyte apoptosis plays a role in chronic hepatitis C pathogenesis; evaluation of  the presence of different apoptotic markers that correlate with liver injury in HCV- related liver diseases could be a way for this achievement. The aim of the present study was to identify the correlation between serum apoptotic markers Bcl-2 and Bax with hepatitis C viral load in the chronic hepatitis C virus related liver diseases. The study included three groups ; group 1: 35 compensated  chronic HCV patients without any suspected evidence of liver cirrhosis and with Child - Pugh score of 5-6 (class A), Group 2: 35 decompensated chronic HCV patients with Child - Pugh score of 10-15 (class C) and group 3: 15  healthy volunteers as a control group. The results collectively suggest that statistically significant correlations were noticed between serum Bcl-2, Bax, Bcl-2/Bax ratio and HCV PCR in chronic hepatitis C virus-related liver disease.