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34948

Postmastectomy hypofractionation comparison with conventional radiotherapy in breast cancer patients: A prospective study

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Last updated: 24 Dec 2024

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Abstract

Background: Postmastectomy radiotherapy reduces loco-regional recurrence among womenwith operable breast cancer and improves survival for up to 10 years.
Objectives: Conventional fractionated radiotherapy (CF) has been limited by patient'scompliance, travelling, unplanned interruption and others. Hypofractionated (HF) schedule wouldbe more appealing and convenient for both patients and radiotherapists. We prospectively testedfor OS, DFS, locoregional control, and treatment related toxicities, in patients treated with CFand HF schedules.
Methods: 47 patients suffering from cancer breast stage T2-4, any N, underwent surgery andreceived adjuvant systemic and radiation therapies. These patients were scheduled for adjuvantradiotherapy and randomly divided into two groups; CF (n = 162), and HF (n = 181).The logrank test examined differences in OAS and DFS rates. Data of radiation toxicities, and diseaserelapse in both CF and HF groups were compared using Chi-square test.
Findings: The median follow up was 34 months (range: 13 – 53 months). Four-year OAS ratesfor the both groups were 98 % with 100% for CF and 96% for HF group, and with no significantdifference (P value= 0.37). The 4 year disease free survival rate for both were 87% with 81% and 92% for CF and HF respectively (p-value= 0.47) and HR= 0.52 (0.09-2.13). As regard treatment related toxicity, 3 patients (12%) of HF group had toxicity compared with 1 patient (4.5%) in CF, yet, not statistically significant.
Interpretation: these data showed that HF 42 Gy radiotherapy in 16 fractions was not inferior,safe and comparable to CF in terms of OAS, loco-regional tumor control and toxicities. These results need to be tested in large scale multicenter randomized control trials.

DOI

10.21608/smj.2018.34948

Keywords

breast cancer, Hypofractionation, Survival

Authors

First Name

Asmaa

Last Name

Abo Agag

MiddleName

AE

Affiliation

Department of Clinical oncology, Faculty of Medicine, Sohag University, Sohag, Egypt.

Email

asmaa_aboagag@med.sohag.edu.eg

City

Sohag

Orcid

-

First Name

Mohammed

Last Name

S

MiddleName

Ael

Affiliation

Department of Clinical oncology, Faculty of Medicine, Sohag University, Sohag, Egypt.

Email

-

City

Sohag

Orcid

-

First Name

Al Sayed

Last Name

Hassan

MiddleName

M

Affiliation

Department of Clinical oncology, Faculty of Medicine, Sohag University, Sohag, Egypt.

Email

elsayed_ali@med.sohag.edu.eg

City

Sohag

Orcid

-

First Name

Magdy

Last Name

Abdel Majid

MiddleName

Khalil

Affiliation

Department of Surgery, Faculty of Medicine, Sohag University, Sohag, Egypt.

Email

magdy_khalil@med.sohag.edu.eg

City

Sohag

Orcid

-

First Name

Mohmed

Last Name

Gaber

MiddleName

Soliman

Affiliation

Department of Clinical Oncology ,FacultyofMedicine,Sohag University.

Email

mohamed_marzouk@med.sohag.edu.eg

City

Sohag

Orcid

-

Volume

22

Article Issue

2

Related Issue

4798

Issue Date

2018-07-01

Receive Date

2018-05-28

Publish Date

2018-07-01

Page Start

71

Page End

83

Print ISSN

1687-8353

Online ISSN

2682-4159

Article File

SMJ_Volume 22_Issue 2_Pages 71-83.pdf

PDF . 138.6kB

Link

https://smj.journals.ekb.eg/article_34948.html

Detail API

https://smj.journals.ekb.eg/service?article_code=34948

Order

10

Type

Original Article

Type Code

785

Publication Type

Journal

Publication Title

Sohag Medical Journal

Publication Link

https://smj.journals.ekb.eg/

MainTitle

Postmastectomy hypofractionation comparison with conventional radiotherapy in breast cancer patients: A prospective study

Details

Type

Article

Created At

22 Jan 2023