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31575

Electroanalytical determination of Azapropazone at Glassy Electrode Using Differential Pulse and Anodic Square-Wave Voltammetry in Pure Formulation and Pharmaceutical Formula

Article

Last updated: 03 Jan 2025

Subjects

-

Tags

Medicine

Abstract

A sensitive electroanalytical method for determination of azapropazone  has been  investigated on the basis of the enhancement electrochemical response at glassy carbon electrode during oxidation of azapropazone, Cyclic voltammetric undergo one irreversible anodic peak at Ep = 0.48  mV in Britton - Robinson (BR) (pH 4.0). Cyclic voltammetric study indicated that the oxidation process is irreversible and adsorption controlled. The number of exchanged electrons in the electro -oxidation process was obtained. Differential pulse voltammetry (DPV) and square wave voltammetry (SWV) were studied and a linear calibration obtained from: 0.0014– 0.026µg/ml, 0.014–0.134µg/ml using DPV and SWV respectively. The RSD for five measurements were found in the ranges: 0.854% and 0.911% for DPV and SWV, respectively. Precision and accuracy of the developed method was checked by recovery studies. The method was applied to determine azapropazone in pure form, pharmaceutical formulations, and compared with official methods.

DOI

10.21608/sjou.2017.31575

Keywords

Azapropazone, Voltammetry, Differential pulse, cyclic voltammetry and square wave voltammetry

Authors

First Name

H.

Last Name

Hendawy

MiddleName

A. M.

Affiliation

National Organization for Drug Control and Research, (NODCAR) P.O. Box 29, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

A. A.

Last Name

Amin

MiddleName

wassel1, A. S.

Affiliation

Department of Chemistry, Faculty of Science, Benha University, Benha, Egypt

Email

-

City

-

Orcid

-

First Name

H.

Last Name

Dessouki

MiddleName

A.

Affiliation

Department of Chemistry, Faculty of Science, Benha University, Benha, Egypt

Email

-

City

-

Orcid

-

First Name

I.

Last Name

Ahmed

MiddleName

S.

Affiliation

Department of Chemistry, Faculty of Science, Benha University, Benha, Egypt

Email

-

City

-

Orcid

-

Volume

3

Article Issue

1

Related Issue

5252

Issue Date

2017-01-01

Receive Date

2014-12-05

Publish Date

2017-01-01

Page Start

28

Page End

32

Print ISSN

2314-8640

Online ISSN

2356-8119

Link

https://sjou.journals.ekb.eg/article_31575.html

Detail API

https://sjou.journals.ekb.eg/service?article_code=31575

Order

4

Type

Original Article

Type Code

724

Publication Type

Journal

Publication Title

Scientific Journal of October 6 University

Publication Link

https://sjou.journals.ekb.eg/

MainTitle

Electroanalytical determination of Azapropazone at Glassy Electrode Using Differential Pulse and Anodic Square-Wave Voltammetry in Pure Formulation and Pharmaceutical Formula

Details

Type

Article

Created At

22 Jan 2023