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213965

Epidemiological Study and Clinical Characteristics of Crohn's Disease in The West Algerian Population

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Last updated: 22 Jan 2023

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Abstract

Background: Crohn's disease (CD) is a chronic multifactorial inflammatory disorder, characterized by discontinuous lesions that affect the entire gastrointestinal tract from the mouth to the anus. The aim of our work was focused more particularly on the study and determination of epidemiological data, clinical, para-clinical and therapeutic aspects of Crohn's disease in the Western Algerian population. Methods: A retrospective analytical study was carried out at the level of the general surgery department (western Algeria), during the period 2008-2019. Results: During the period of our study, which ran from 2008-2019, we collected 300 cases of Crohn's disease. 184 males and 116 females with a sex ratio of 1.6. Anemia, ESR and CRP were the most impaired biological noted signs. The ileo-caecal location was the most dominant (56%) and the most common phenotype was the inflammatory type (47%). Statistical analysis showed an evidence association between Colic location, ilea-caecal location and gender ( p=0.005; p=0.017). Similarly, we noted a significant relation between Colic location, ilea-caecal location and < 40-year group (P=0.007, p=0.005 respectively). The treatment of Crohn's disease was essentially medical. Nevertheless, surgery remains necessary in most patients as 79% underwent it. Postoperative morbidity was dominated by the occurrence of recurrence (83%). As major risk factors, we noted appendectomy at 17%, smoking at 22.7% and oral contraception at 32%. Conclusions According to our results Crohn's disease is a frequent pathology, its care remains multidisciplinary despite a well-conducted medical treatment and complicated cases are frequently observed. The therapeutic sanction remains surgical which does not protect the patient from the occurrence of recurrence.

DOI

10.21608/eajbsc.2022.213965

Keywords

Crohn disease, Epidemiology, clinical aspect, para-clinical aspect, therapeutic aspect, morbidity

Authors

First Name

Benaissa

Last Name

Zahira

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Affiliation

Laboratory of Molecular Microbiology Health and Proteomics, Biology Department, Faculty of Natural Sciences and Life, Djillali Liabés University of Sidi-Bel-Abbés, BP No. 89 Sidi-Bel-Abbés 22000 Algeria.

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Orcid

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First Name

Noria

Last Name

Harir

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Affiliation

Laboratory of Molecular Microbiology Health and Proteomics, Biology Department, Faculty of Natural Sciences and Life, Djillali Liabés University of Sidi-Bel-Abbés, BP No. 89 Sidi-Bel-Abbés 22000 Algeria.

Email

harirnouria@yahoo.fr

City

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Orcid

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First Name

Habbar

Last Name

Aicha

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Affiliation

National Research Center of Biotechnology. RCBt

Email

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Orcid

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First Name

Ouali

Last Name

Siheme

MiddleName

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Affiliation

Laboratory of Molecular Microbiology Health and Proteomics, Biology Department, Faculty of Natural Sciences and Life, Djillali Liabés University of Sidi-Bel-Abbés, BP No. 89 Sidi-Bel-Abbés 22000 Algeria.

Email

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City

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Orcid

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First Name

Sellam

Last Name

Feriel

MiddleName

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Affiliation

National Research Center of Biotechnology. RCBt

Email

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City

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Orcid

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First Name

El Mehadji

Last Name

Douniazad

MiddleName

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Affiliation

Laboratory of Molecular Microbiology Health and Proteomics, Biology Department, Faculty of Natural Sciences and Life, Djillali Liabés University of Sidi-Bel-Abbés, BP No. 89 Sidi-Bel-Abbés 22000 Algeria.

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City

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Orcid

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First Name

Belhandouz

Last Name

Lahcen

MiddleName

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Affiliation

Department of digestive and laparoscopic surgery, UHC Sidi-Bel-Abbés, Algeria

Email

-

City

-

Orcid

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First Name

Elaib

Last Name

Mustapha

MiddleName

-

Affiliation

Department of digestive and laparoscopic surgery, EHC Oran, Algeria

Email

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City

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Orcid

-

First Name

Kanoun

Last Name

Khedoudja

MiddleName

-

Affiliation

Laboratory of Molecular Microbiology Health and Proteomics, Biology Department, Faculty of Natural Sciences and Life, Djillali Liabés University of Sidi-Bel-Abbés, BP No. 89 Sidi-Bel-Abbés 22000 Algeria

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Volume

14

Article Issue

1

Related Issue

29927

Issue Date

2022-06-01

Receive Date

2021-11-28

Publish Date

2022-06-01

Page Start

47

Page End

54

Print ISSN

2090-0767

Online ISSN

2090-083X

Article File

EAJBSC_Volume 14_Issue 1_Pages 47-54.pdf

PDF . 602.0kB

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https://eajbsc.journals.ekb.eg/article_213965.html

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https://eajbsc.journals.ekb.eg/service?article_code=213965

Order

5

Type

Original Article

Type Code

673

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

Publication Link

https://eajbsc.journals.ekb.eg/

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Article

Created At

22 Jan 2023