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246775

Protective Effect of Honey Against Zinc Oxide Nanoparticles' Toxicity in Maternal and Foetal Livers of Rat

Article

Last updated: 03 Jan 2025

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Abstract

Zinc oxide nanoparticles (ZnO-NPs) used in many industries such as the food industry as additives and are a group of high crystallinity-nano particles. It is a toxic substance, especially when inhaled due to Zn2+ ion that is probably the main toxic material in vivo.
        The present work was planned to study the protective effect of honey on pregnant rats' livers which received ZnO-NPs and their fetal livers. The pregnant rats were divided into six groups each was 6:8 pregnant rats. The first group served as a control group and received the distilled water. The 2nd group was administered 10 ml/kg per day of honey from the 6th to 15th day of gestation. The 3rd and 4th groups were administrated two doses of ZnONPs (10 and 50 mg/kg/day) respectively from the 6th to 15th day of gestation. The 5th and 6th groups received 10 ml/kg per day of honey before administration of ZnONPs (10 and 50 mg/kg/day). Animals of all groups received the administrated materials orally then they were sacrificed on the 20th day of gestation. The obtained results showed an increase in the pathological changes in the liver and an increase in the changes in the liver function with the two doses of ZnONPs as compared to the normal control group. Using natural honey reduces the histopathological changes caused by ZnONPs administration.

DOI

10.21608/eajbsz.2022.246775

Keywords

Teratology, Honey, Zinc Oxide, Nanoparticles

Authors

First Name

Nehad

Last Name

Ibrahim

MiddleName

M.

Affiliation

Zoology and Entomology Dep., Faculty of Science, Helwan University.

Email

nehadmohamedibrahim@yahoo.com

City

-

Orcid

-

First Name

Asmaa

Last Name

Kandil

MiddleName

M.

Affiliation

Pharmacology Dep., National Organization for Drug Control and Research (NODCAR).

Email

-

City

-

Orcid

-

First Name

Ranina

Last Name

Ali.

MiddleName

S.

Affiliation

Zoology and Entomology Dep., Faculty of Science, Helwan University.

Email

-

City

-

Orcid

-

First Name

Ranya

Last Name

Yahya

MiddleName

-

Affiliation

Pharmacology Dep., National Organization for Drug Control and Research (NODCAR).

Email

-

City

-

Orcid

-

First Name

Yasmin

Last Name

Mansour

MiddleName

-

Affiliation

Zoology and Entomology Dep., Faculty of Science, Helwan University.

Email

-

City

-

Orcid

-

First Name

Maiada

Last Name

Moustafa

MiddleName

-

Affiliation

Zoology and Entomology Dep., Faculty of Science, Helwan University.

Email

-

City

-

Orcid

-

Volume

14

Article Issue

1

Related Issue

29870

Issue Date

2022-01-01

Receive Date

2022-05-13

Publish Date

2022-06-30

Page Start

283

Page End

294

Print ISSN

2090-0759

Online ISSN

2090-0821

Link

https://eajbsz.journals.ekb.eg/article_246775.html

Detail API

https://eajbsz.journals.ekb.eg/service?article_code=246775

Order

22

Type

Original Article

Type Code

672

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences, B. Zoology

Publication Link

https://eajbsz.journals.ekb.eg/

MainTitle

Protective Effect of Honey Against Zinc Oxide Nanoparticles' Toxicity in Maternal and Foetal Livers of Rat

Details

Type

Article

Created At

22 Jan 2023