The term "Hydatidiform Mole" refers to a group of abnormal gestations caused by villous trophoblastic associated with pregnancy. Aim: The present study aimed to evaluate the effect of supportive educational guidelines about hydatidiform mole on women's knowledge, satisfaction, compliance with treatment and follow up. Design: A quasi-experimental pre posttest design was utilized to achieve the aim of this study. Setting: The study was carried out at Hydatidiform Mole Outpatient Clinic at the Gynecological Hospital in Mansoura University Hospitals, Mansoura City, Dakahlia Governorate, Egypt. Subjects: A convenient sample of sixty women was divided into intervention and control groups each containing thirty women. Tools: A structured interviewing questionnaire schedule was used to assess socio-demographic women's characteristics, obstetric history, knowledge regarding hydatidiform mole, compliance with treatment and follow up as well as the satisfaction level among the intervention group. Results: In terms of general characteristics and obstetric history, there was no statistically significant difference between the studied groups. Nonetheless, statistically significant differences in all issues of hydatidiform mole knowledge were found between the studied groups. Furthermore, highly statistically significant differences were found among the intervention group regarding satisfaction level about supportive educational guidelines provided. Conclusion: Supportive educational guidelines about hydatidiform mole had a positive effect on women's knowledge, compliance with treatment and follow-up among the intervention group compared to control group. In addition, the intervention group was more satisfied with supportive educational guidelines. Recommendation: Applying supportive educational guidelines about hydatidiform mole should be a one of the routine hospital cares before and after evacuation.