Background: The existence of a pandemic disease such as COVID-19 may raise the disease's risk among children, which can have several negative implications, including increased concern and anxiety among mothers over their children's health and physical and mental well-being. Aim: To investigate the effect of social-platform psycho-educational regarding children's health on mothers' knowledge, practice, and anxiety during covid-19 outbreak. Design: A quasi-experimental research design was used to accomplish this study. Setting: This study was applied in Egypt at Sohag City. Sample: - A total purposive sample of 400 mothers from 10 and 30 May 2020 by using an online questionnaire via Google Form. Tools: Four tools were utilized: Tool I: Mothers' knowledge regarding covid-19, Tool II: Mothers' practice regarding covid-19, Tool III: Future anxiety scale, and Tool IV: Mothers'satisfaction with social-platform psychoeducational interventions. Results: The study findings revealed that mothers had a higher score of knowledge and practical knowledge post- social-platform psychoeducational interventions compared to pre-intervention regarding COVID-19. There was a decrease in the studied mothers' anxiety levels during COVID-19 post the social-platform psychoeducational interventions. There was a positive correlation between mothers' total knowledge, practical knowledge, and anxiety. scores at the 0.01 level of significance regarding COVID-19 post-intervention. Conclusion: The study concluded that social-platform psychoeducational interventions regarding their children's health during Covid-19 Outbreak have a positive effect on improving mothers' knowledge, and practice, and reducing their anxiety levels. Recommendations: Providing mothers with a well-planned health education program to improve their knowledge and practice regarding Covid -19 and reinforce possible interventions is essential to support and help in psychological adjustment.