Background: Workforce agility can help health care organizations in dealing with change and it can be started by increasing work innovation and proactive initiatives as staff nurses should make work innovations according to performance demands. The study aimed to assess the relationship between workforce agility and staff nurses' innovative work behavior at Critical Care Units. Research design: Descriptive correlational design was utilized. The study setting: the study was conducted at critical care units in Benha University Hospital. The study sample: A convenient sample of (265) staff nurses from the setting mentioned above. Tools: Two tools were used for data collection; Workforce agility Scale and Innovative Behavior Inventory. Results: Slightly more than half of staff nurses had moderate level of workforce agility and more than two thirds of studied staff nurses had high innovative work behavior. Conclusion: There was a highly statistical significant positive correlation between workforce agility and staff nurses' innovative work behavior. The study recommended: that nurse manager should give staff nurses the time and resources they need to pursue creative ideas, and support innovation as a job requirement, conduct training program about workforce agility and enable knowledge and new ideas to be shared.