Background: Despite the growing demand for blood and its products, some people, particularly the
youth, are reluctant to donate blood. Aim: To evaluate the effect of the orientation program on
undergraduate nursing students' performance regarding blood donation. Subjects and method:
Design: A quasi-experimental research design was used to achieve the aim of this study. Setting:
The study was conducted at the Faculty of Nursing, Minia University, Egypt on the undergraduate
nursing students. Subjects: The sample consisted of convenient 900 undergraduate nursing students
selected from the previous setting. Tool: A self-administered related questionnaire was designed
using an electronic survey (Google form) which included four parts: Part I: undergraduate nursing
students' demographic characteristics, Part 2: undergraduate nursing students' knowledge regarding
blood donation, Part 3: undergraduate nursing students' attitudes regarding blood donation, Part 4:
undergraduate nursing students' practices regarding blood donation. The link to the survey was sent
to the respondents via WhatsApp groups. Results: The study result revealed that more than one
third of studied undergraduate nursing students had a poor level of knowledge, and more than half
of them had an inadequate level of practice about blood donation before the implementation of the
program. The majority of students had a good level of knowledge and most of them had a
satisfactory level of practice after implementing the program. There was a highly statistically
significant difference and improvement in undergraduate nursing students' knowledge, attitude, and
practice after program implementation than pre-implementation. Conclusion: The findings of the
study concluded that orientation program had positive effects on improving undergraduate nursing
students' performance regarding blood donation. Recommendations: The study recommended
organized blood donation orientation program are required to increase undergraduate nursing
students' knowledge, attitudes, and practices toward blood donations.