Change fatigue is an overwhelming emotion of stress, tiredness, and burnout caused by feelings of
ambivalence and impotence in the workplace. In addition to personal stress, change fatigue may
negatively affect nurses' job satisfaction and psychological resilience and increased the turnover of
nurses. Aim: Explore the relationship between change fatigue, psychological resilience, and job
satisfaction of nursing staff at Mansoura university hospital. Subjects& Methods: a correlation
descriptive design was applied, and conducted among 187 nursing staff working at Mansoura
University Hospitals. Data were collected from nursing staff by using three tools via Google form:
(a) Change Fatigue scale, (b) Connor-Davidson Resilience scale, and (c) McCloskey/Mueller
Satisfaction Scale. Results: reveals that there is a correlation between change fatigue, job
satisfaction, and psychological resilience. Change fatigue had a statistically significant negative
correlated with psychological resilience. There is a statistically significant positive correlation was
present between sub-scales of job satisfaction and staff nurses' place of work, nurses who had
diplomas, and those aged more than 45 years. A statistically significant difference was present
between staff nurses' who work at (Urology center), nurses' experience (6-10 years), and
psychological resilience domain. Conclusion: Nursing Staff's offered important insight into the
effect of change fatigue on their psychological resilience and job satisfaction. Nursing staff are
negatively influenced by change fatigue and positively influenced by resilience.
Recommendations: This work was recommended that using measures to reduce change fatigue in
nursing staff, which can improve nurse job satisfaction and workplace conditions. Offering
psychological resilience training programs and a comprehensive approach to change fatigue
management may counter-act these negative effects of change fatigue.