Children spend the majority of their time at school, where they are exposed to a variety of small injuries, all of which have an impact on their current and future health. Before professional medical assistance is available, first aid is used to treat any accident or illness. The teacher is the most important person who can attend to minor injuries in the classroom by having a thorough understanding of first aid. Aim to evaluate the effect of structured educational package on primary school teachers' knowledge and practice regarding first aid management among school children. Subjects and method: Design: A quasi-experimental research design was utilized to achieve the aim of this study. Setting: the research was conducted in five primary schools in Beni- Suef City. Subjects: By applying the non-probability purposive sampling technique, 200 primary school teachers were selected for the study from the previously selected settings. Tools: A self- administered questionnaire was used in this study; it includes three parts: Primary school teachers' demographic data, primary school teachers' first aids knowledge, and primary school teachers' first aids reported practices. Results: The study results revealed that the mean post-test knowledge score regarding first aid management was significantly higher than that of the mean pretest knowledge score; the mean post-test reported practices score was significantly higher than the mean pretest practical knowledge score. There was a positive correlation (P=0.005) between primary school teachers ' knowledge and their practice scores post- structured educational package implementation regarding first aid management. Conclusion: The study concluded that the first-aid structured educational package implementation for primary school teachers had a positive effect on improving their knowledge and practice. Recommendation: Implementation of the structured educational package is highly recommended for all primary school teachers to improve their first-aid knowledge and reported practices. Further research should be conducted to evaluate the impact of such a structured educational package on school health safety and child health.