Background: Change fatigue is an overwhelming emotion of stress, tiredness, and burnout
caused by feelings of ambivalence and impotence in the workplace. In addition to personal stress,
change fatigue may negatively affect nurses' job satisfaction and psychological resilience and
increased the turnover of nurses. Aim: Explore the relationship between change fatigue,
psychological resilience, and job satisfaction of nursing staff at Mansoura university hospital.
Subjects& Methods: a correlation descriptive design was applied, and conducted among 187
nursing staff working at Mansoura University Hospitals. Data were collected from nursing staff by
using three tools online via Google form: (a) Change Fatigue scale, (b) Connor-Davidson Resilience
scale, and (c) McCloskey/Mueller Satisfaction Scale. Results: reveals that there is a correlation
between change fatigue, job satisfaction, and psychological resilience. Change fatigue had a
statistically significant negative correlated with psychological resilience. There is a statistically
significant positive correlation was present between sub-scales of job satisfaction and staff nurses'
place of work, nurses who had diplomas, and those aged more than 45 years. A statistically
significant difference was present between staff nurses' who work at (Urology center), nurses'
experience (6-10 years), and psychological resilience domain. Conclusion: Nursing Staff's offered
important insight into the effect of change fatigue on their psychological resilience and job
satisfaction. Nursing staff are negatively influenced by change fatigue and positively influenced by
resilience. Recommendations: This work was recommended that using measures to reduce change
fatigue in nursing staff, which can improve nurse job satisfaction and workplace conditions.
Offering psychological resilience training programs and a comprehensive approach to change
fatigue management may counter-act these negative effects of change fatigue.