Background: Nurses are the most precious assets of any health-care institution, thus it's critical to understand their behavior. In this regard, the present study was carried out in order to examine the effect of communication skills training program for head nurses on interpersonal relations and nurses' organizational commitment. This study was carried out at Zagazig University Hospitals, using quasi experimental design. A convenience sample of 50 head nurses and simple random sample of 221 staff nurse from the previously mentioned setting. Tools:  A questionnaire sheet was used to collect data for this study that was composed of three parts; Organization Communication Questionnaire, Fundamental interpersonal relation orientation - behavior questionnaires and organizational commitment scale. Results revealed that there was significant improvement in head nurses' communication skills mean score after the program implementation (P < 0.01). As well, there was statistically significant enhancement in their interpersonal relations with nurses mean score (P < 0.01). Additionally, there was a statistically significant improvement in nurses' organizational commitment after the program implementation (P < 0.01). Conclusion: communication skills training program for head nurses is effective in improving interpersonal relations and commitment of their nurses. Recommendation: hospital administration should establish training activities to offer nurses with key skills such as active listening, accurate feedback, and problem-solving techniques.