Background: ACS is a common, life-threatening condition due to decreased blood
flow in the coronary arteries. Simulation is one of the approaches that could lead healthcare
students to construct their knowledge and skills comprehensively within complex clinical
situations. Aim: This study was done to assess the effect of high fidelity simulation on
nursing students' knowledge and skills regarding assessment and nursing intervention of
acute coronary syndrome (ACS). Hypothesis: nursing students who undergo high fidelity
simulation program show improvement in knowledge and skills regarding acute coronary
syndrome. Design: quasi experimental research design. Setting: critical care lab in faculty of
nursing at Alexandria University hospital. Subject: Convenient sample of approximately
forty critical care nursing students. Tools: Two tools were used in this study acute coronary
syndrome assessment questioner (tool I), performance checklist about acute coronary
syndrome (tool II). Methods: The current study was carried out on four phases; assessment,
preparation, implementation and evaluation. Assessment of the baseline nursing students'
knowledge and skills were done using (tool I, tool II) before the preparation of teaching
program and all nursing students were received the lecture about ACS and scenario case by
using human patient simulation. Assessment of nursing students' knowledge and skills was
done using (tool I, II) immediately after the implementation of teaching program and
scenario case by using human patient simulation. Results: A statistical significant
improvement was found between the nursing student knowledge and skills before and
immediately after application of teaching program with scenario case by using human patient
simulation. Conclusion: The level of nursing students' knowledge and skills were general
improved after application of teaching program with simulation learning strategy about ACS.