Background: Nurses more than other health care workers (HCWs) are susceptible to
numerous job-related hazards, as acquiring infection of Covid-19 and burnout syndrome due
to their nature of their occupations. Aim of the study: to evaluate the effect of
multidimensional nursing interventions on reducing risk of infection and burnout syndrome
among nurses caring Covid-19 patients. Design: Quasi Experimental design used to conduct
this study. Setting: The current study was carried out at isolation setting for Covid 19-
patient (isolation ward and ICU) at Menoufia University Hospital. Subject: a convenience
sample of 62 nurses caring Covid-19 patients at intensive care unit and isolation ward was
selected. Tools of the study: four tools used to collect the current data: Tool I: A structured
interviewing questionnaire about burnout syndrome. Tool II: Questionnaire for assessing
Burnout symptoms; Tool III: Questionnaire for Assessment Nurses compliance of prevented
measures for Burnout Prevention and Tool IV: Observational checklists for Protection and
preventions procedures. The results: after interventions most of studied nurses had good
level of knowledge and practices regarding burnout management and infection control
procedures; reduction of nurses' burnout symptoms after intervention within the different
measurements; additional incidence rate of Covid-19 infection decreased. Conclusion:
implementation of multidimensional nursing interventions was successful in reducing
burnout symptoms and risk of infection among studied nurses. It was effective to improve
nurses' knowledge and practice. Recommendation: establishing educational program or
workshop on burnout management for all hospital nurses and nurse supervisors. Perform
periodic evaluation of stressors at work place for nurses.