Background: The improvement of health literacy in general is a major concern worledwide. We
assumed that mothers of children who are recieving treatment for leukaemia experience practical
challenges in caring for their children. Treatment adherence and improved health outcomes for
children with Leukemia require easily understandable of caregivers for health information.
Objective: To evaluate the effect of pictorial information booklet on mothers' care of their children
with Leukemia in Cairo, Egypt. Methods: Design of this study was A quantitative, quasi
experimental pre-posttest group design. The samplewere 65 mothers who had children with
leukemia in Cairo, Egypt. A pectorial information booklet was given, and in the post-test period the
same structured knowledge questionnaire was used. Practice was assessed using the interview
method by direct observation. Results: The findings revealed that 78.5% of mothers had
unsatisfactory knowledge regarding leukemia pre education program while 86.2% of them had
satisfactory knowledge regarding leukemia post education program with highly statistically
significant differences between pre and post education program using pictorial information booklet
(p < 0.000). Approxmitly 76.9% of mothers had adequate total practice regarding Leukemia post
education program with highly statistically significant differences between pre and post education
program using pictorial information booklet (p < 0.000). Conclusion: Based on the study findings, it
can be concluded that the pectorial information booklet effectively improved mothers' knowledge
and practices regarding care of their children with leukemia. Recommendations: It is
recommended that future studies investigate mothers improvement in knowledge and practices as
well as retention of knowledge over an extended period of time.