Background: As nurses develop their talents, talent management is crucial for helping them add unique value and benefit hospitals. Aim: To assess how a training program in talent management affects nurses' empowerment. Design: A Quasi experimental study with a single-group pre-posttest approach was employed. Setting: Fayoum University hospitals served as the research site. Subjects: For the study, 145 nurses were selected. Tools: Talent management and empowerment questionnaires were the two tools used. Results: Following program implementation, the talent management dimensions' overall score was higher (63.6720±8.71111) than it was before the intervention phase (36.4640±3.24421). Furthermore, the overall empowerment dimension score among nurses was low (162.8080±11.56935) prior to program implementation, but it improved (273.2400±28.81515) after program implementation. Conclusion: There was a statistically significant positive association between total talent management and total empowerment among nurses across all intervention stages. In addition, the degree of empowerment of the participants was enhanced by the implementation of a talent management training program. Recommendations: Newly recruited staff courses and/or training programs should be offered to improve staff efficiency. All healthcare organizations must incorporate a talent management strategy into their strategic planning to remain competitive in the modern healthcare market.