Nursing care protocol daily sedation is very important to optimize sedation for patients on
mechanical ventilators, these requires nursing staff is very crucial in this aspect to avoid
complication of sedation and earlier extubation. Aim: This study was aimed to identify impact
nursing care protocol for daily interruption sedation on mechanical ventilation patients outcome.
Design: a quasi-experimental design. Setting: Carried at ICU at Assiut university hospital.
Subjects: A purposive sample of 70 adults patients. Sample was assigned to two equal groups
(study and control). Tools: Four tools were utilized to collect data of study, tool I: Patient
assessment sheet. Tool II: Interruption and infusion sedation assessment scales tool. Tool III:
Intensive Care Delirium Screening Checklist. Tool IV:patients outcome tool. Results: the present
study revealed that there was a statistical significant differences (P<0.001**) between study and
control groups in relation to sedative complication, Delirium , ICU stay, and Duration of mechanical
ventilation. Conclusion: Patient who received nursing care protocol during daily interruption of
sedation leading to improve outcome and reduce complication. Recommendation: Provide in
service education and training program for critical care nurses regarding applying daily interruption
of sedation and how managed these patients