Nowadays, nurses should prepare themselves for pandemic events as far in advance as potentially
worsening outbreak conditions. Coronavirus disease (COVID-19) is a widespread pandemic
disease, especially in a health-care setting. But there are not enough researches done to control &
prevent it from transmission among health-care providers. The pandemic has highlighted how
protecting the healthy team is key to keeping patients safe and ensuring a functioning health system.
Therefore, nurses should have sufficient knowledge and practice about pandemic events through
using safety measures in dealing with COVID-19 patients to protect themselves from physical and
biological hazards. Aim: Investigate the impact of educational programs regarding safety measures
guidelines on nurses' knowledge, attitude, and practice toward COVID-19 patients. Design: Quasi
experimental design. Setting: Medical, surgical, and oncology departments at the Alexandria Main
university hospital, Egypt. Sample: A convenience sample of 150 nurses. Results: There was a
positive, statistically significant difference between pre & post-educational programs regarding
safety measures on studied nurses' knowledge, attitude, and practice. A positive, statistically
significant correlation between studied nurses' knowledge of the safety measures educational
program and their attitude and practice. Conclusion: the educational programs regarding safety
measures guidelines improved nurses' knowledge, attitude, and practice toward COVID-19 patients.
Recommendations: Efforts should be made to enhance nurses' knowledge, attitude, and practices
through periodical follow-up.