Bronchial asthma is a major public health issue that affects children all over the world, with varying levels of prevalence and severity. Aim: To compare the effect of mobile-based education versus booklet-based education on mothers' knowledge and practice towards their children with bronchial asthma. Design: A quasi-experimental research design was used to achieve aim of the study. Setting: The study was conducted in Pediatric Chest Outpatient Clinic at Sohag University Hospital. Subjects: A purposive sample of 230 mothers of asthmatic children was included (115 in the experimental group were taught using mobile Whats app application and 115 in the control group were taught using a booklet). Four tools were used: Tool I Astructuredinterviewingquestionnaire including two parts. Part (1): Demographic data of the mothers and part (2): Demographic data of the asthmatic children, Tool II Asthma Trigger Inventory, Tool III Asthma Knowledge Questionnaire, and Tool IV Asthma Self-Management Questionnaire. Results: The knowledge and practice of both mobile-based and booklet-based groups regarding bronchial asthma were low pre-program implementation. The mobile-based education groups showed an improvement in their total level scores of knowledge and practice one month after mobile-based education versus booklet-based education implementation compared to booklet-based education groups, with highly significant differences (p < 0.001). Less school absenteeism was associated with improved practice of mothers. There were statistically significant correlations between total knowledge and self-management scores. Conclusion: Mobile-based education was more effective in improving mothers' knowledge and practice about bronchial asthma management than booklet-based education. Recommendations: Health care providers can use mobile-based educational methods for mothers of asthmatic children to promote their health.