Background: Nurses are very vital and valuable asset of hospitals. A hospital's success might not be realized without its nurses' support and involvement. Nurses need to be motivated to be able to provide quality of patient care and retain in their work place. Aim: this study aimed to assess the influence of motivation on staff nurses' intention to quit Research design: A descriptive correlational design used in this study. Setting: Ain Shams University hospitals. Study subjects243staff nurses were included in the study, simple random sample was used. Data collection: two tools used to collect data motivation scale and staying or leaving index, Results: about half of studied subjects had low motivation level,less than one quarter of studied staff nurses had high motivation level, less than half of studied staff nurses had moderate level of intention to quit. Conclusion: There was statistically significant correlation between motivation and intention to quit. Recommendations: conducting periodical meeting between hospital mangers and staff nurses to discover work problems and develop solutions for these problem. Hospital management has to appreciate staff nurses sharing in decision making.