Low birth weight infants are a special group that needs attention and care. The study aims to improve mother's care of low birth weight infants at home. Research design: It is A quasi- experimental design were used in this study. Setting: This study were conducted at Neonatal Intensive Care Unit (NICU) of Ain Shams Maternity Hospital and at mother's home. Sampling: A purposeful sample were used in this study, 20% of total admitted rate equal to 122 of mothers of low birth weight infant and were chosen randomly according to criteria.Tools: Two tool were used for data collection, An interviewing questionnaire for mothers to assess their socio demographic characteristics and their knowledge, checklist to assess mothers' practices, and Observational checklist for assessing home environment. Results: The study showed highly statistically significance differences between the mother's socio-demographic and their knowledge and practice, highly statistically significance positive correlation between mothers and their practice and knowledge. Recommendation: the study recommended to conduct an educational program for the high risk pregnant women in the follow up clinic to raise their knowledge and practices related to their low birth weight infant..