Aim: The current study aimed to assess the effect of simulation on maternity nursing students, perception, satisfaction and self-confidence. Setting: The study was conducted at maternity skills laboratory, Faculty of Nursing, Benha University. Design: A descriptive study was utilized. Sampling: A convenient sampleof 151 students. Tools: Three tools were used to collect data, structured interviewing questionnaire, simulation design scale, student satisfaction and self-confidence in learning. Results: 53.6% and 46.3%of the students had moderate level of perception and satisfaction regarding simulation activities, 49% of the students had high level of self-confidence in learning regarding simulation activities. There was statistically significant positive correlation between total perception, satisfaction and self-confidence score (p=0.000). Conclusion: Students had moderate level of perception and satisfactionin learning regarding simulation activities and had high level of self-confidence in learning regarding simulation activities. Recommendation: Students should be provided by variety of simulation-based education on maternity nursing skills to increase level of perception, satisfaction and self-confidence.