An instructional brochure should positively affects student's knowledge related to self body exam. This study aimed to evaluate the effect of an instructional brochure on technical institute student's knowledge related to self-body exam. An intervention study was utilized. The study was conducted at Port-Said City, in Health Technical Institute, and Technical Institute of Nursing Health Insurance. The subjects involved unmarried female student nurse at first academic year 2014 – 2015 and their age ranged from 18 to 20 years old so, the sample size was 63 students. Data were collected through two Tools (a questionnaire sheet and Follow up card). The study revealed that there was a significance difference between pre and post implementation (one & two month) of an instructional self body exam brochure related to knowledge among technical institute student. The study concluded that an instructional brochure is effective on enhancing students' level of knowledge related to self body exam among technical institute students. The researcher recommended integrating an instructional brochure regarding self body exam at all Technical health Institute. Further researches are needed to explore the barriers that confront knowledge of an instructional brochure regarding self body exam among technical institute students.