Background: Diabetes and associated amputation are major challenges that threaten
patient's quality of life (QoL). Well fitting prosthesis is considered as a turning point in restoring
amputee's life through improving physical functioning, body image, work capacity, and social
participation. This study was aiming to evaluate the effect of intervention program on quality of
life of diabetic patients with lower limb prosthesis. A quasi experimental design was utilized to
meet the aim of the study. The study was conducted on a purposive sample of 60 diabetic patients
with lower limb prosthesis who were divided into study and control groups. The study was
conducted at Orthopaedic Industries Work Shop's clinics that is affiliated to Agouza Rehabilitation
& Rheumatology Center of the Army. Data were collected using 1) Interviewing Questionnaire
including the following parts: A) Socio demographic characteristics, B) Patient's clinical data
sheet, C) Patients' level of knowledge regarding diabetes and prosthesis. 2) Quality of life of
diabetic patients with prosthesis questionnaire. The result of this study showed that there were
highly statistically significant differences between study and control groups post intervention
regarding total knowledge about diabetes and prosthesis, which represent (p < 0.001). Additionally,
there were highly statistically significant differences between study and control groups post
intervention regarding total dimensions of quality of life, which represent (p < 0.001). As well as,
majority of study group had moderate level of quality of life post intervention. This study
concluded that the implementation of intervention program had a positive effect on quality of life
of diabetic patients with lower limb prosthesis. This study recommended that development of
preparatory psycho-educational program for diabetic patients with limb amputation prior to using
prosthetic limb to enhance psychosocial adjustment after using prosthesis.