Background: Organization synergy system is a new language based on respect, diversity, boundaries and communication. Aim: This study aimed to investigate the effect of organizational synergies system on Staff Nurses' performance and patients' satisfaction. Study design: A quasi-experimental research design was used to conduct this research. Setting: The study was conducted in (CCU) at El Orman Hospital at Assiut University Hospitals. Subject: Convenience sample of Staff Nurse (N= 12) working in (CCU) at El Orman Hospital and this study was consisted of 60 patients. Methods: The data were collected using: Organizational Synergies System Scale was used and contained two parts: Part (I): As regard to nurses include the Personal data, and Nursing Competency Scale and Part (II) as regard to patient included Socio- demographic data and Patient Satisfaction assessment tool. Results: The study revealed that head nurses had unsatisfactory knowledge level in preprogram assessment but satisfactory in post program implementation (66.7%) with statistical significant relation. and the highest percentages of patient satisfactory about nurses communication & nurses' skills and competences. Conclusion: There was positive correlation between nurse's knowledge and total performance categories. Recommendation: Further training about organizational synergies system for all nurses working at other intensive care units.