Background: Toxemia of pregnancy remains an important cause of maternal mortality throughout the world; it is a common problem in developing countries Aim: Aim of the study was to assess nurses‟ knowledge and practical skills provided for mothers with toxemia of pregnancy. Setting: The study was conducted at obstetrics and gynecology departments at Benha university hospital. Design: A descriptive study design was utilized. Sampling: A convenient sample included 50 nurses. TOOLS: structured interviewing schedule, an observational check list and satisfaction assessment sheet. Results: The present study revealed that 66.7% of the studied nurses had correct knowledge regarding toxemia of pregnancy, 68.9% of the nurses had satisfactory regarding total practice score, 31.1% of them had unsatisfactory practice score, while 68.9% of the studied mothers had satisfied score regarding nursing practice. while, only 8.9% of them had dissatisfied score., Conclusion: nurse's knowledge and practices regarding care provided to toxemic mothers had correct &satisfactory score for nurses working in obstetric department at Benha university hospital. Most of studied mothers with toxemia of pregnancy are satisfied regarding nursing care provided for them. Recommendations: Developing continuous educational programs for nurses working in obstetrics and gynecology department to enhance their knowledge and practices regarding care with toxemia of pregnancy, Establishing design and implement standard of care for toxemic mothers. While in-services, pre services & on job training programs.