Aim: Assessing training needs of the staff nurses regarding implementing an educational program on dealing with High Alert Medication (HAM). Subjects and methods: The study was conducted in the International Medical Center (IMC) which affiliated to Ministry of Defence. The subjects of this study consisted of 180 nurses who are working in IMC full time with experience at least one year. 89 nurses were working in critical care units while 91 nurses were working in medical- surgical units. Data were collected using needs assessment tool. Results:Some topics show the lowest mean score and participants are in need to study these topics as:Side effects, contraindications, hazards, storage of HAM, international standards of patient safety and the most common nursing errors during dealing with HAM. Recommendations: Establish an educational program for all nurses to inform them how to deal with HAM including topics that met their educational needs. Conclusion:Based on the present study findings, it can be concluded thatnurses are needed forestablishing an educational program to gain their knowledge and Performance regarding dealing with HAM