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273063

Study of the Effect of Glycated Albumin Compared to Glycated Hemoglobin as An Indicator of Blood Glucose in Haemodialysis Patients Suffering from Diabetes Mellitus

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Last updated: 03 Jan 2025

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Abstract

Background: The prognosis of individuals with diabetes mellitus (DM) and chronic renal disease who get regular hemodialysis (HD) is improved by strict glycemic management. Glycated haemoglobin (HbA1c) may not be a useful test for glycemic management in certain patients. Objective: We aimed to assess the efficacy of glycated albumin (GA) versus HbA1c, as a glycemic control indicator, in diabetic patients on HD.  Patients and methods: In between 2016 and 2017; a total of 75 subjects were included in the study. Participants were divided into 3 groups: Group 1; diabetic patients on HD (n=50), Group 2; diabetics with normal renal function (n=10) and Group 3; control group (n=15). Through history and clinical evaluation was performed. GA and HbA1c were done in all groups. Results: diabetic patients on HD had significantly higher GA, while HbA1c was significantly higher in those diabetic patients with normal renal function. GA had 87.1% sensitivity and 72.73% specificity at a cutoff point >31% for prediction of uncontrolled DM in those patients on regular HD while HbA1c had 72% sensitivity and 73% specificity at a cutoff point >6.7%. GA had 67% sensitivity and 85% specificity at a cutoff point >27% for prediction of uncontrolled DM in those patients with normal renal function, while HbA1c had 67% sensitivity and 71% specificity at a cutoff point >7.9%. Conclusion: Glycated albumin could be used as an indicator for glycaemic control in patients on regular HD. Future studies are warranted to confirm such findings.  

DOI

10.21608/ejhm.2022.273063

Keywords

Glycated albumin, glycated hemoglobin, End Stage Renal Disease, haemodialysis, Diabetes mellitus

Authors

First Name

Mina Misheal Welson

Last Name

Azab

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Email

mina.welson_mmw@yahoo.com

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First Name

Essam Abdelmohsen

Last Name

Mohamed

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Volume

89

Article Issue

2

Related Issue

37472

Issue Date

2022-10-01

Receive Date

2022-12-06

Publish Date

2022-10-01

Page Start

7,189

Page End

7,194

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_273063.html

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https://ejhm.journals.ekb.eg/service?article_code=273063

Order

161

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Study of the Effect of Glycated Albumin Compared to Glycated Hemoglobin as An Indicator of Blood Glucose in Haemodialysis Patients Suffering from Diabetes Mellitus

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Article

Created At

22 Jan 2023