Beta
266047

Fatty Acid Binding Protein (1 & 2) as Markers of Diabetic Nephropathy in Elderly Patients with Type 2 Diabetes Mellitus

Article

Last updated: 03 Jan 2025

Subjects

-

Tags

-

Abstract

Background: The 15kDa cytoplasmic fatty acid-binding protein family (FABPs) is one of the most exciting novel indicators for the diagnosis of renal damage. Objective: The aim of this study was to investigate the relation of circulating FABP1 and FABP2 levels as clinical and biochemical markers and varying stages of nephropathy in senior T2DM patients. Patients and Methods: This case-control study included a total of 60 patients with Type 2 diabetes and 30 nondiabetic controls, attending and followed up at Out-Patient Clinics, Department of Internal Medicine, Zagazig University Hospitals. Patients were divided into 3 equal groups: Group I: healthy control group; Group II: diabetic group without incidence of diabetic nephropathy; Group III: diabetic nephropathy group. All patients were tested for FABP1 and FABP2. Results: FABP1 and FABP2 levels significantly varied among the study's three groups. The significance was referred to the higher expression of FABP1 and FABP2 in group II and III than controls and higher expression in group III than group II as illustrated in post-hoc analysis. There were significant positive Pearson correlations between FABP1, FABP2 and serum creatinine, serum urea, urine albumin-creatinine ratio (uACR) while the correlation between FABP1, FABP2 and eGFR was inverse correlation of significance. Conclusion: It could be concluded that FABP1 and FABP2 may be novel biomarkers of diabetic nephropathy. FABP1 has an 87% sensitivity and an 83% specificity for the diagnosis of diabetic nephropathy at a cut-off value equal to 2.7 ng/dL. FABP2 has a 93% sensitivity and a 33% specificity for diagnosing diabetic nephropathy at a cut-off value equal to 0.16 ng/dL.  

DOI

10.21608/ejhm.2022.266047

Keywords

Fatty Acid Binding Protein, diabetic nephropathy

Authors

First Name

Mohamed Mohamed Mohamed

Last Name

Hassaan

MiddleName

-

Affiliation

-

Email

-

City

-

Orcid

-

First Name

Asmaa Mahmoud Elsayed

Last Name

Elsayed

MiddleName

-

Affiliation

-

Email

asmaashady836@gmail.com

City

-

Orcid

-

First Name

Hamed Abdelaziz

Last Name

Deraz

MiddleName

-

Affiliation

-

Email

-

City

-

Orcid

-

First Name

Atef Goda

Last Name

Hussein

MiddleName

-

Affiliation

-

Email

-

City

-

Orcid

-

Volume

89

Article Issue

1

Related Issue

36332

Issue Date

2022-10-01

Receive Date

2022-10-18

Publish Date

2022-10-01

Page Start

5,778

Page End

5,783

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_266047.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=266047

Order

259

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Fatty Acid Binding Protein (1 & 2) as Markers of Diabetic Nephropathy in Elderly Patients with Type 2 Diabetes Mellitus

Details

Type

Article

Created At

22 Jan 2023