Multiple myeloma (MM) is a monoclonal plasma cell proliferative disease characterized by primary bone marrow infiltration and excessive production of abnormal monoclonal immunoglobulin. The aim of the present study is to assess the detection of bony lesions in patients with MM using whole-body diffusion-weighted imaging with background body signal suppression (WB-DWIBS). Patients and methods: A prospective study was conducted on 28 consecutive patients (18 males, 10 females); mean age 55 (SD 9) years with pathologically proven MM, who underwent WB-DWIBS on a 1.5-T MR scanner. Image analysis was performed and numbers of bony lesion were recorded according to affection of each anatomical site. For this study, we compared the number of lesions detected by T1, STIR and DWIBS. Results: Our results showed that DWIBS was able to detect a large number of lesions compared toT1and STIR, but yet did not reach statistical significance (P value >0.05). Conclusion: that WB-MRI using morphological sequences and the DWIBS technique is a reliable imaging modality for detection of MM lesions, whether focal, diffuse or combined. DWIBS was able to detect larger number of lesions than morphological sequences yet did not reach statistical significance.