Background: For a long time, full median sternotomy was the standard approach for heart surgery. With the advancement of the new technology there is a trend for minimal invasion in all types of surgeries including heart surgery aiming to avoiding and minimizing surgical trauma and morbidity. Objective: The aim of the current work was to compare the outcome of right mini-thoracotomy aortic valve replacement versus full sternotomy. Patients and Methods: A retrospective study that was done in multicentre in in Cairo University and Beni-Suef University. Between June 2015 to October 2021, 219 patients had aortic valve replacement for aortic valve disease of them 124 had the surgery through full sternotomy and 95 patients had it through right mini thoracotomy. We collected their clinical data and compared their inpatient course and outcome. Results: Right mini-thoracotomy was associated with more aortic cross clamp, total bypass and total surgery time, but less mechanical ventilation, blood loss, blood transfusion, ICU stay, re-exploration for bleeding than the full sternotomy group. Also, it was associated with less wound complications with no significant difference in mortalities in both groups. In addition, it had shorter hospital stay that was 6.9 ± 0.8 days (mean ±SD) in comparison to 8.2 ± 1.1 days (mean ±SD) in the full sternotomy group with a p value of 0.02. Also, right mini-thoracotomy showed more patient satisfaction and shorter wound than the full sternotomy group.Conclusion: It could be concluded that right Mini-thoracotomy aortic valve replacement is safe alternative to full sternotomy with shorter MV, ICU and inpatient stay, less wound infection, smaller wound and more patient satisfaction but with longer cross clamp, bypass and surgery time.