Background: In general surgery, the most common technique is inguinal hernia repair. A mesh prosthesis is implanted ventral to the transversalis fascia in the Lichtenstein repair. After the introduction of tension-free surgical repair with the use of prosthetic mesh, patients' comfort was reported to be significantly improved over that acquired by traditional, tension-producing procedures. The use of cyanoacrylate (CA) to secure the mesh may result in better results and reduce tension on the pubis, muscles, and nerves. Objectives: Our study aimed to clarify the efficacy and complications of cyanoacrylate glue and nonabsorbable sutures for mesh fixation in Lichtenstein hernia repair techniques. Matrials and Method: Prospective observational study for 6 months at General Surgery Department, Zagazig University Hospitals. 24 patients were divided into two groups. Group A undergoes hernioplasty using glue for mesh fixation and group B using sutures fixation. Patients were followed for 6 months for post-operative pain, recurrence, and complication. Results: In our analysis the mean age of glue group was 50 ± 7 years, while in the sutures group it was 49.3 ± 6.7 years. Mean operation time in the glue group was 41.2 ± 5.1 min, while in the sutures group it was 47.6 ± 4.9 min with statistically significantly higher mean operation time in the sutures group. There was no substantial difference between the two groups after a considerable period of follow-up. Conclusion: Histoacryl glue appears to be a promising alternative for mesh attachment in Lichtenstein inguinal hernia repair. According to our data, it showed replication of tissue integration and mechanical behavior of sutures while requiring less time to do. It's also associated with a decrease in persistent inguinal pain.