Background: The most prevalent cause of thyrotoxicosis is Graves' disease. It can be treated with antithyroid medications (ATD), radioactive iodine (RAI), or a near-total thyroidectomy, among other options.
Objective: The aim of the current study was to compare between different therapeutic modalities for the management of patients with Graves disease.
Patients and Methods: This Prospective Cohort study included a total of 48 patients with Graves' disease, treated and followed up at the Endocrinology Unit, Department of Internal Medicine, Faculty of Medicine, Zagazig University and both Outpatient Clinics and Medical Departments of Tripoli Medical Center. All patients were subjected to clinical examination of thyroid gland, thyroid function tests (FT3, FT4, TSH) and measurement of thyroid stimulating hormone receptor autoantibodies (TRAb) level.
Results: There was statistically significant difference of mean TRAb value before and after treatment in three therapeutic modalities. On other hand, there was marked decreased mean TRAb after treatment with different modalities; difference statistically significant p < 0.05. The decline percent of TRAb values were 97.41%, 93.48%, 82.01% by surgical modalities, GI modalities and GII modalities respectively.
Conclusion: It could be concluded that surgery appear to be the useful therapeutic modality associated with significant decrease in TRAb level and inducing remission of graves' disease.